Nomogram of Rouzier et al for Predicting Complete Pathologic Response of a Breast Cancer to Preoperative Anthracycline Chemotherapy

Description

Rouzier et al developed a nomogram for predicting the probability of a complete pathologic response to preoperative anthracycline chemotherapy. This can help identify patients who are likely to benefit from this therapy. The authors are from University of Texas Houston M.D. Anderson Cancer Center, Institut Gustave Roussy in Villejuif, and Hotel-Dieu in Beirut.

Parameters:

(1) estrogen receptor (ER) status

(2) initial T stage (TNM)

(3) histologic grade

(4) age of the patient in years

(5) number of courses of the anthracycline chemotherapy

Parameter	Findings	Points
estrogen receptor	positive	0
	negative	46
T stage	T0	100
	T1	75
	T2	50
	T3	25
	T4	0
histologic grade	Grade 1	0
	Grade 2	49
	Grade 3	98
number of courses	3	0
	4	60

points for age =

= (-1.21 * (age in years)) + 91.5

where:

• The maximum age is 75 years, with 0 points. For ages > 75 years 0 points will be assigned.

total score =

=SUM(points for all 5 parameters)

Interpretation:

• minimum score: 0

• maximum score: around 364

Total Score	Probability of Complete Pathologic Response
< 163	< 5%
163 - 325	(0.001443 * ((points)^2)) - (0.4105 * (points)) + 33.65
> 325	continue with quadratic formula (51 - 66%)

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Nomogram of Rouzier et al for Predicting Complete Pathologic Response of a Breast Cancer to Preoperative Anthracycline Chemotherapy

Description

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