Nomogram of Ouldamer et al for Predicting a Prognosis for a Woman with Endometrial Cancer

Description

Ouldamer et al reported a nomogram for predicting the prognosis of a patient with endometrial cancer. This can help to identify a patient who may benefit from more aggressive management. The authors are from multiple institutions in France belonging to the FRANCOGYN study group.

Patient selection: woman with endometrial cancer confined to the corpus uteri

Parameters:

(1) age in years

(2) surgical nodal staging (sentinel lymph node; pelvic or para-aortic lymphadenopathy)

(3) histologic type

(4) histologic grade

(5) lymphovascular space invasion

(6) FIGO stage (primary tumor confined to corpus uteri)

Parameter	Finding	Points
age in years	< 60 years	0
	>= 60 years	50
surgical nodal staging	no	75
	yes	0
histologic type	I (endometrioid)	0
	II (serous, clear cell, carcinosarcoma)	92
histologic grade	I (well-differentiated)	0
	II	50
	III (poorly-differentiated)	98
lymphovascular space invasion	no	0
	yes	100
FIGO stage	I	0
	II	60
	III	65

total score =

= SUM(points for all 6 parameters)

Interpretation:

• minimum score: 0

• maximum score: 480

• The higher the score the worse the prognosis.

value of X =

= (-0.00002202 * ((score)^2)) + (0.0002084 * (score)) + 2.954

Total Score	Probability of 3-Year Relapse-Free Survival
< 196	> 90%
>= 196	1 / (1 + EXP((-1) * X))

Performance:

• The area under the ROC curve is 0.82 for the training set and 0.75 for the validation set.

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Nomogram of Ouldamer et al for Predicting a Prognosis for a Woman with Endometrial Cancer

Description

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