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Nomogram of Liu et al for Recurrence of an Early Hepatocellular Carcinoma After Radiofrequency Ablation (RFA)

Description

Liu et al developed a nomogram for evaluating a patient with early-stage hepatocellular carcinoma. This can help to decide if a patient can be managed by radiofrequency ablation or requires surgical resection. The authors are from Taipei Veterans General Hospital, National Yang-Ming University and the University of Nevada.


Patient selection: early hepatocellular outcome, 1 to 3 tumors, largest 5.0 cm

 

Outcome: recurrence-free survival (time frame not clearly specified but appears to be up to 3 years) after radiofrequency ablation

 

Significance: lower recurrence-free survival would favor surgical resection

 

Parameters:

(1) number of tumors

(2) diameter of largest tumor in cm

(3) serum albumin in g/dL

(4) MELD score

(5) platelet count per microliter

 

Parameter

Finding

Points

number of tumors

1

0

 

2

4.3

 

3

10

diameter in cm

<= 2.0 cm

0

 

2.1 to 3.0 cm

4

 

3.1 to 5.0 cm

6.3

serum albumin

>= 4.0 g/dL

0

 

< 4.0 g/dL

3.8

MELD

< 8

0

 

>= 8

3

platelet count

>= 150,000 per µL

0

 

< 150,000 per µL

3

 

total score =

= SUM(points for all 5 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 26.1

• The higher the score the worse the recurrence-free survival.

 

Total Score

Recurrence-Free Survival

0 to 23.8

(-0.0002703*((score)^2)) - (0.02155 * (score)) + 0.8444

> 23.8

< 19%

 


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