Hu et al reported a nomogram for predicting chemotherapy-induced nausea and vomiting in a cancer patient. The authors are from multiple hospital in Taiwan.
Patient selection: Chinese cancer patient receiving chemotherapy, from ages 20 to 80 years
Parameters:
(1) age in years (from 20 to 80 years)
(2) body surface area (from 1.2 to 2.2 square meters)
(3) gender
(4) history of vomiting during pregnancy if female
(5) history of alcohol consumption
(6) emetogenicity of chemotherapy
(7) antiemetic therapy
points for age in years =
= (-0.61667 * (age in years)) + 49.333
points for body surface area =
= (-83 * (body surface area)) + 182.6
|
Parameter |
Finding |
Points |
|
gender and vomiting during pregnancy |
Male |
0 |
|
|
female, no vomiting during pregnancy |
45.6 |
|
|
female with vomiting during pregnancy |
100 |
|
history of alcohol use |
No |
35.5 |
|
|
Yes |
0 |
|
history of motion sickness |
No |
0 |
|
|
yes |
6.7 |
|
chemotherapy |
highly emetogenic |
45 |
|
|
not highly emetogenic |
0 |
|
antiemetic therapy |
1 drug |
52 |
|
|
2 drug |
44 |
|
|
3 drugs |
0 |
where:
• The text says "vomiting pregnancy". This may refer to hyperemesis gravidarum.
where:
• Everyone got at least 1 antiemetic drug.
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 359.2
• The higher the score the greater the risk of CINV.
|
Score |
Percent with CINV |
|
< 68 |
< 10% |
|
68 to 330 |
(0.000282 * ((points)^2)) + (0.1694 * (points)) - 4.357 |
|
> 330 |
> 80% |
Performance:
• The area under the ROC curve was 0.67 in the training set.
Specialty: Hematology Oncology, Pharmacology, clinical
