Patient selection: renal cell carcinoma with venous invasion and thrombus
Outcome: 2-year overall suvrival
Parameters:
(1) histologic type
(2) invasion of the collecting system
(3) metastases present at surgery
(4) AST to ALT ratio (De Ritis Ratio)
(5) serum albumin in g/L, from 25 to 60
points for AST to ALT ratio =
= 25 * (ratio)
points for serum albumin =
= 153.257 - (2.554 * (albumin))
Parameter
|
Finding
|
Points
|
histologic type
|
clear cell
|
0
|
|
other
|
32.5
|
invasion of collecting system
|
no
|
0
|
|
yes
|
11.5
|
metastases
|
no
|
0
|
|
yes
|
39
|
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 272.4
• The higher the score the worse the overall survival.
value of X =
= (-0.0001426 * ((score)^2)) - (0.004345 * (score)) + 2.909
probability of 2-year overall survival =
= 1 / (1 + EXP((-1) * X))