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Nomogram of Groot Koerkamp et al for Survival After Resection of a Perihilar Cholangiocarcinoma (PHC)

Description

Groot Koerkamp et al reported a nomogram for a patient undergoing resection of a perihilar cholangiocarcinoma (PHC). This can help to identify a patient who may benefit from more aggressive or a novel therapy. The authors are from Memorial Sloan Kettering Cancer Center, Erasmus Medical Center and Academic Medical Center in Amsterdam.


Patient selection: perihilar cholangiocarcinoma (PHC)

 

Outcome: 5-year disease-specific survival (DSS)

 

Parameters:

(1) surgical margins of resection

(2) lymph node status

(3) histologic differentiation of the tumor

 

Parameter

Finding

Points

surgical margins

wide

0

 

narrow

43.4

 

positive

77

lymph node status

N0, <= 4 examined

32

 

N0, > 4 examined

0

 

N1 or N2

100

histologic differentiation

wel-differentiated

0

 

moderately differentiated

80

 

poorly differentiated

80

 

total score =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 257

• The higher the score the worse the 5-year disease-specific survival.

 

Total Score

5-Year Disease Specific Survival

< 28

> 70%

28 to 187

(0.81546 - (0.0038617 * (score))

187 to 257

(0.000012611 * ((score)^2)) - (0.0068916 * (score)) + 0.94795

 


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