Patient selection: prostate cancer
Parameters:
(1) PSA at diagnosis in ng/mL from 0 to 80
(2) clinical stage at multi-parametric magnetic resonance imaging (MRI)
(3) grade group at MRI-targeted biopsy
(4) maximum diameter of the index lesion on multi-parametric MRI in mm from 0 to 45
(5) percentage of core biopsies with clinically significant prostate cancer at systematic biopsy
points for PSA =
= 1.25 * (PSA)
points for maximum diameter of index lesion =
= 0.93111 * (diameter)
points for percentage of core biopsies =
= 0.356 * (percent)
|
Parameter
|
Finding
|
Points
|
|
clinical stage
|
organ-confined
|
0
|
|
|
extracapsular extension
|
36.1
|
|
|
seminal vesicle invasion
|
44
|
|
Grade group
|
1 (score <= 6) or 2 (3+4)
|
0
|
|
|
3 (4+3)
|
35.6
|
|
|
4 (4+4) or 5 (9 or 10)
|
54.4
|
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 275.9
• The higher the score the greater the risk of lymph node metastases.
|
Score
|
Percentage with Lymph Node Invasion
|
|
< 20
|
< 2%
|
|
20 to 203
|
X = (0.033264 * (score)) - 4.5668;
probability = 1/(1+EXP((-1) * X))
|
|
> 203
|
> 90%
|
Performance:
• The area under the ROC curve was 0.86.
