Nomogram of Albert et al for Predicting the Benefit of Radiation Therapy in an Older Woman with Breast Cancer After Conservative Surgical Resection

Description

Albert et al developed a nomogram for an older woman with breast cancer undergoing conservative surgical resection. This can help to determine if radiation therapy is likely to benefit the patient. The authors are from the University of Texas M.D. Anderson Cancer Center and the University of Chicago.

Patient selection: age 66 to 79 with favorable breast cancer treated conservatively

Parameters:

(1) age in years

(2) race

(3) tumor diameter in cm

(4) estrogen receptor (ER) status

(5) lymph node status and radiation therapy

Parameter	Finding	Points
age in years	66 to 69 years	20
	70 to 74 years	26
	75 to 79 years	0
race	white	16.7
	black	42.2
	other	0
tumor size	<= 2.0 cm	0
	> 2 cm	15.5
er status	positive	0
	borderline	50
	negative	50
lymph node status and radiation	clinically negative and no radiation	88.7
	clinically negative and radiation	0
	pathologically negative and no radiation	67.7
	pathologically negative and radiation	23.3
	pathologically positive and no radiation	100
	pathologically positive and radiation therapy	26.4

total score =

= SUM(points for all 5 parameters)

Interpretation:

• minimum score: 0

• maximum score: 234

• The higher the score the worse the mastectomy-free survival (MFS).

Score	5-year MFS survival
< 35	> 99%
35 to 131	100.2 – (0.03143 * (score))
131 to 234	(-0.001156 * ((score)^2)) + (0.2171 * (score)) + 87.11

Score	10-year MFS survival
< 78	> 95%
78 to 234	(-0.001767 * ((score)^2)) + (0.256 * (score)) + 85.5

To read more or access our algorithms and calculators, please log in or register.

Nomogram of Albert et al for Predicting the Benefit of Radiation Therapy in an Older Woman with Breast Cancer After Conservative Surgical Resection

Description

Specialty