Nodular colloid degeneration may rarely involve the tongue.
Pathogenesis: uncertain, probably degenerative
Clinical findings:
(1) yellowish nodules, plaques or macules, sometimes with a cobblestone pattern
(2) variable presence of similar lesions in the skin, which may be pruritic
A biopsy shows:
(1) eosinophilic amorphous material with clefts in histologic sections
(2) There are fragmented elastic fibers at the periphery and in the colloid material
Differential diagnosis:
(1) xanthoma
(2) amyloid
