Nodular colloid degeneration may rarely involve the tongue.

Pathogenesis: uncertain, probably degenerative


Clinical findings:

(1) yellowish nodules, plaques or macules, sometimes with a cobblestone pattern

(2) variable presence of similar lesions in the skin, which may be pruritic


A biopsy shows:

(1) eosinophilic amorphous material with clefts in histologic sections

(2) There are fragmented elastic fibers at the periphery and in the colloid material


Differential diagnosis:

(1) xanthoma

(2) amyloid

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