The National Institute of Neurologic and Communicative Disorders and Stroke (NINCDS) and Alzheimer's Disease and Related Disorders Association (ADRDA) proposed criteria for the clinical diagnosis of probable Alzheimer's disease in 1984..
Criteria for clinically probable Alzheimer's disease:
(1) dementia demonstrated on clinical examination (mental status examination) and confirmed on neuropsychological testing
(2) deficits in 2 or more cognitive domains (memory, attention, language, personality, visuospatial functions, executive functions)
(3) progressive deterioration in cognitive domains
(4) delirium absent (clear sensorium present)
(5) age of onset between 40 and 90 years of age (usually > 65 years of age)
(6) exclusion of other disorders that can affect the brain and cause dementia
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