The National Institute of Health INIH) Oral chronic Graft-versus-Host Disease (cGVHD) Activity Assessment can be used as an objective measure of disease activity over time.
Patient selection: oral changes of graft-versus-host disease
Parameters:
(1) erythema
(2) lichenoid change
(3) mucosal ulcers
(4) mucoceles (lower labial and soft palate only)
Parameter
Finding
Points
erythema
none
0
mild or moderate < 25%
1
moderate >= 25%, severe < 25%
2
severe >= 25%
3
lichenoid change
none
0
hyperkeratosis < 25%
1
hyperkeratosis 25-50%
2
hyperkeratosis > 50%
3
mucosal ulcers
none
0
involve <= 20%
2
severe (> 20%)
3
mucoceles
none
0
1 to 5
1
6 to 10
2
> 10
3
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 12
• The higher the score the more severe the condition.
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