Patient selection: woman with breast cancer
Parameters:
(1) Nottingham score (from 3 to 9)
(2) estrogen receptor immunohistochemical score (ERIHC, from 0 to 300)
(3) progresterone receptor immunohistochemical score (PRIHC, from 0 to 300)
(4) Ki-67 index (from 0 to 100)
(5) HER2/neu
(6) tumor size in cm
ER or PR IHC =
= (percent cells staining 1+) + (2 * (percent cells staining 2+)) + (3 * percent of cells staining 3+))
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Points for HER2
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Points if Negative
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Points if Equivocal
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Points if Positive
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|
for Equation 1
|
0
|
0.77681
|
11.58134
|
|
for Equation 2
|
0
|
1.82921
|
11.51378
|
|
for Equation 3
|
0
|
1.46495
|
12.75525
|
total score for equation 1 =
= (1.4055 * (Nottingham score)) – (0.01924 * (ERIHC)) – (0.02925 * (PRIHC)) + (points for HER2) + (0.78677 * (tumor size)) + (0.13269 * (Ki-67 index)) + 15.31385
total score for equation 2 =
= (2.34123 * (Nottingham score)) – (0.03749 * (ERIHC)) – (0.03065 * (PRIHC)) + (points for HER2) + (0.0.04267 * (tumor size)) + 18.8042
total score for equation 3 =
= (1.4055 * (Nottingham score)) – (0.01924 * (ERIHC)) – (0.02925 * (PRIHC)) + (points for HER2) + (0.78677 * (tumor size)) + (0.13269 * (Ki-67 index)) + 15.31385
