New agents:
(1) patiromer (patiromer calcium sorbitex, Veltassa), a potassium-absorbing resin
(2) sodium zirconium cyclosilicate (ZS-9, Lokelma), a nonabsorbable, inorganic crystal which selectively binds potassium and ammonium
Patiromer
(1) slower onset of reduce potassium, suited for chronic management
(2) gastrointestinal complaints (constipation, diarrhea)
(3) risk of hypomagnesemia
Sodium zirconium cyclosilicate:
(1) more rapid onset of reduced potassium, suited for acute management
(2) low rate of adverse effects (dose-dependent edema, gastrointestinal complaints)
Advantages over sodium polystyrene sulfonate:
(1) fewer side effects
(2) greater reduction in potassium
