A patient with primary hyperparathyroidism may experience a number of cognitive and psychiatric problems, some of which improve after parathyroidectomy. Some of the problems may be related to neural excitability secondary to an elevated concentration of serum calcium.


Neuropsychiatric problems in a patient with primary hyperparathyroidism may include:

(1) lethargy and fatigue

(2) drowsiness

(3) depression

(4) neurasthenia

(5) anxiety

(6) paranoia

(7) hallucinations

(8) disorientation

(9) confusion

(10) impaired memory and forgetfulness

(11) increased sleeping

(12) mood swings

(13) irritability


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