Diabetes insipidus (DI) may occur as a result of a disease affecting the hypothalamus and/or posterior pituitary gland.


A key clue to the diagnosis is a low or absent serum vasopressin (ADH) concentration.


Conditions associated with neurophypophyseal (central) diabetes insipidus:

(1) benign cyst or tumor (craniopharyngioma, other)

(2) primary malignant tumor (suprasellar germnoma, other)

(3) metastatic cancer

(4) hematologic malignancy

(5) head trauma

(6) brain surgery

(7) Langerhans cell histiocytosis

(8) sarcoidosis

(9) Wegener's granulomatosis or other vasculitis

(10) infection (tuberculosis, other)

(11) lymphocytic infundibulohypophysitis

(12) panhypopituitarism


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