Neurogenic Muscular Hypertrophy and Pseudohypertrophy

Clinical presentation:

(1) muscular enlargement, which may be asymmetrical or symmetrical

(2) possibly muscle weakness

In hypertrophy there is an increase in skeletal muscle.

In pseudohypertrophy the apparent muscle enlargement is due to infiltration by fat or other tissue. This can be identified on ultrasonography.

Conditions associated with hypertrophy may include:

(1) spinal muscular atrophy and spinal muscular atrophy-like disorders

(2) conditions with continuous muscle fiber stimulation (myokymia, neuromyotonia)

(3) radiculopathy

(4) Charcot-Marie-Tooth disease

Conditions associated with pseudohypertrophy may include:

(1) diabetic neuropathy

(2) poliomyelitis