Positron emission tomography (PET) scans using a radiolabeled compound has revolutionized the imaging of neuroendocrine tumors. The use of a compound that binds specifically to a receptor in the tumor has significantly improved performance.
Reasons to perform imaging studies on a neuroendocrine tumor:
(1) To identify the source for an elevated level of a hormone or secretory product.
(2) To determine if a neuroendocrine tumor may have metastasized.
(3) To identify where metastases from a neuroendocrine tumor are located.
(4) To monitor response to therapy.
Recommendations for the use of imaging studies:
(1) Combine a positron emission tomography (PET) scan with a CT or MRI scan.
(2) Use the optimum probe for the PET scan.
Neuroendocrine Tumor |
Probe for PET Scan |
Full Name |
carcinoid tumor |
18F-DOPA |
18F-dihydroxy-phenyl-alanine |
islet cell tumor |
11C-5-HTP |
11C-5-hydroxy-tryptophan |
pheochromocytoma |
18F-DOPA |
18F-dihydroxy-phenyl-alanine |
Other modalities that have been used:
(1) 123I-metaiodobenzylguanidine (MIBG) scintigraphy
(2) fluro-2-deoxy-D-glucose PET (looks for tumor metabolic activity)
(3) 68Ga-DOTATE (a somastatin analogue) PET
(4) 111Indium pentetreotide (Octreoscan, somatostatin analogue) scintigraphy
Purpose: To scan a patient with a neuroendocrine tumor.
Specialty: Hematology Oncology, Surgery, general, Endocrinology
Objective: imaging studies
ICD-10: E27.5, C18.1,