Description

Positron emission tomography (PET) scans using a radiolabeled compound has revolutionized the imaging of neuroendocrine tumors. The use of a compound that binds specifically to a receptor in the tumor has significantly improved performance.


 

Reasons to perform imaging studies on a neuroendocrine tumor:

(1) To identify the source for an elevated level of a hormone or secretory product.

(2) To determine if a neuroendocrine tumor may have metastasized.

(3) To identify where metastases from a neuroendocrine tumor are located.

(4) To monitor response to therapy.

 

Recommendations for the use of imaging studies:

(1) Combine a positron emission tomography (PET) scan with a CT or MRI scan.

(2) Use the optimum probe for the PET scan.

 

Neuroendocrine Tumor

Probe for PET Scan

Full Name

carcinoid tumor

18F-DOPA

18F-dihydroxy-phenyl-alanine

islet cell tumor

11C-5-HTP

11C-5-hydroxy-tryptophan

pheochromocytoma

18F-DOPA

18F-dihydroxy-phenyl-alanine

 

Other modalities that have been used:

(1) 123I-metaiodobenzylguanidine (MIBG) scintigraphy

(2) fluro-2-deoxy-D-glucose PET (looks for tumor metabolic activity)

(3) 68Ga-DOTATE (a somastatin analogue) PET

(4) 111Indium pentetreotide (Octreoscan, somatostatin analogue) scintigraphy

 


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