Egami et al reported a case of linear IgA bullous dermatosis (LABD) in a neonate associated with maternal IgA autoantibodies. The authors are from Keio University, Hokkaido University, and Tokyo Metropolitan Children's Medical Center in Japan.
Patient selection: neonate with bullous dermatosis
Clinical and pathologic features:
(1) neonate with subepidermal blisters showing a neutrophilic infiltrate
(2) demonstration of linear IgA deposits along the basement membrane on immunofluorescence
(3) presence of IgA autoantibodies in maternal milk
(4) exclusion of alternative diagnoses
(5) improvement after discontinuation of feeds with maternal breast milk
Infants with severe mucosal involvement may develop respiratory compromise, which requires more aggressive management.
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