Glucose-6-Phospate dehydrogenase (G6PD) deficiency may present as neonatal hyperbilirubinemia.

Patient selection: neonatal hyperbilirubinemia


Clinical features may include:

(1) family history of G6PD deficiency

(2) hemolytic anemia

(3) onset after exposure to methanol (in powder used to treat the umbilical cord) or a drug that can trigger hemolysis in G6PD deficiency (icterogenic agents)

(4) exclusion of other causes of hyperbilirubinemia (negative direct antiglobulin test, etc)



(1) deficient enzyme activity on red blood cell testing

(2) endogenous production of carbon monoxide (an index of heme catabolism)



(1) bilirubin-induced neurologic dysfunction

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