Negative intrathoracic pressure can result in negative pressure pulmonary edema (NPPE). This can be a life-threatening condition. It may be associated with flash pulmonary edema (see previous section).


Conditions associated with NPPE:

(1) laryngospasm following general anesthesia

(2) acute epiglottitis

(3) strangulation

(4) tracheal compression by a large thyroid goiter

(5) any other cause of upper airway obstruction


Prompt recognition and treatment usually results in rapid resolution.


Complications include:

(1) diffuse intra-alveolar hemorrhage


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