Filipovich et al developed criteria for the severity of chronic graft-versus-host disease (GVHD) for the National Institutes of Health. These include mouth and gastrointestinal tract involvement.
Patient selection: chronic graft-versus-host disease
Parameters:
(1) oral symptoms
(2) oral intake
(3) gastrointestinal symptoms (dysphagia, anorexia, nausea, vomiting, abdominal pain, diarrhea)
(4) weight loss
(5) nutritional supplement
(6) esophageal dilation
|
Parameter |
Finding |
Grade |
|
oral symptoms |
none |
0 |
|
|
mild |
1 |
|
|
moderate |
2 |
|
|
severe |
3 |
|
reduction in oral intake |
none |
0 |
|
|
slight |
1 |
|
|
moderate |
2 |
|
|
major |
3 |
grade for mouth involvement =
= MAX(grade)
|
Parameter |
Finding |
Grade |
|
GI symptoms |
none |
0 |
|
|
mild |
1 |
|
|
moderate |
2 |
|
|
severe |
3 |
|
weight loss |
none |
0 |
|
|
1 to 4.9% |
1 |
|
|
5 to 15% |
2 |
|
|
> 15% |
3 |
|
nutritional support required |
no |
0 |
|
|
yes |
3 |
|
esophageal dilation |
no |
0 |
|
|
yes |
3 |
grade for gastrointestinal involvement =
= MAX(grade)
Specialty: Immunology/Rheumatology
