The National Healthcare Safety Network (NHSN) reported criteria for Ventilator-Associated Event (VAE) in adults. A VAE may or may not be infectious.


Patient selection: on mechanical ventilation.


Pathophysiology of VAE: worsening oxygenation


Requirements for diagnosis of VAE:

(1) established baseline

(2) at least one iindicator present



(1) The patient shows stable or improving daily minimum FIO2 (fraction of oxygen in inhaled air) or PEEP.(positive end-expiratory pressure)

(2) The findings are present for >= 2 calendar days.


The reference values:

(1) minimum FIO2 in the 2 days prior to increase

(2) minimum PEEP in the 2 days prior to increase


Indicators of VAE – one or more of the following:

(1) increase in minimum daily FIO2 >= 0.2 over baseline for >= 2 calendar days

(2) increase in minimum daily PEEP >= 3 cm H2O over baseline for >= 2 calendar days



• The patient needs to be stable or improving for >= 2 calendar days.

• Performance depends on what data is used.


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