Kotronen et al reported a liver fat score for prediction of nonalcoholic fatty liver disease (NAFLD). The authors are from the University of Helsinki, Minerva Medical Research Institute, National Institute for Health and Welfare (Helsinki), University Hospital Malmo, and Lund University.
Parameters:
(1) metabolic syndrome
(2) type 2 diabetes mellitus
(3) fasting serum insulin in mU/L
(4) fasting serum AST in U/L
(5) AST to ALT ratio
Parameter
Finding
Points
metabolic syndrome
no
0
yes
1.18
type 2 diabetes mellitus
no
0
yes
0.90
insulin
0.15 * (insulin)
AST
0.04 * (AST)
AST to ALT ratio
-0.94 * (ratio)
liver fat score =
= SUM(points for all 5 parameters) - 2.889
Interpretation:
• The higher the score the greater the likelihood of NAFLD.
• A score >= -1.413 had a sensitivity of 95% and specificity of 52-56%.
• A score >= -0.640 had a sensitivity of 84-86% and specificity of 69-71%.
• A score >= 1.257 had a sensitivity of 51-59% and specificity of 94-95%.
Performance:
• The area under the ROC curve was 0.86.
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