Cook et al reported the UK Myeloma Research Alliance Risk Profile (MRP) for a myeloma patient who is ineligble for hematopoietic stem cell transplant (HSCT). This can help to identify how fit the patient is to withstand therapy. The authors are from multiple institutions in England and the United States.
Patient selection: multiple myeloma, ineligible for transplant
Parameters:
(1) WHO/ECOG performance status
(2) age in years
(3) International Staging System (ISS), revised by Palumbo et al
(4) serum CRP in mg/L
points for age =
= (0.089 * ((age) - 74.4) /5.4)
points for CRP =
= (0.035 * (LN(CRP+1) - 2.08) / 1.11)
Parameter
Finding
Points
WHO/ECOG performance
0
-0.398
1
-0.199
2
0
3
0.199
4
0.397
ISS
I
-0.212
II
0
III
0.212
total score =
= SUM(points for all of the parameters)
Interpretation:
• The higher the score the greater the risk from therapy.
Score
Category
< -0.256
fit (low risk)
-0.256 to -0.0283
medium risk
> -0.0283
frail (high risk)
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