Wang et al evaluated the impact of comorbidity on survival in patients with myelodysplasia. The authors are from Yale University in New Haven, Connecticut.


Patient selection: myelodysplastic syndrome



(1) A patient without comorbidities lived longer than a patient with comorbidities.

(2) The higher the comorbidity the worse the survival. A patient with a Charlson index >= 3 had a worse outcome than patients with a lower index.


Comorbid conditions associated with a hazard ratio from 1.4 to 2.0):

(1) congestive heart failure

(2) COPD

(3) dementia

(4) mild liver disease (but not moderate or severe)

(5) acute ulcerations (but not chronic)


A patient with significant comorbid disease may not be treated as aggressively as a person who is otherwise healthy.


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