The morphology of myeloma at the time of diagnosis can be used to predict patient survival.
Morphologic categories of plasma cells in the bone marrow:
(1) mature plasma cells
(2) proplasmablasts
(3) plasmablasts
(4) lymphoplasmacytoid cells
Morphology
Content
mature
more than 50% of plasma cells are mature
proplasmablastic
more than 50% of plasma cells are proplasmacytic
plasmablastic
more than 50% of plasma cells are plasmablasts
mixed
no category of plasma cell was more than 50%
Since both the proplasmablastic and mixed types showed a similar prognosis, they were combined into an "immature" group.
Prognosis
best
immature (proplasmablastic and plasmablastic)
intermediate
worst
The presence of renal insufficiency also adversely affects survival.
estimated survival in months =
= 69.0 - (51.45 * (1 if plasmablastic type, else 0)) - (35.03 * (1 if immature subtype, else 0)) - (16.4 * (1 if renal insufficiency present, else 0))
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Specialty: Hematology Oncology
ICD-10: ,
