Description

Tran et al developed a scoring system for multiple organ failure developing in patients receiving intensive care.


Organ systems - 7 evaluated:

(1) cardiovascular

(2) pulmonary

(3) renal

(4) hepatic

(5) hematologic

(6) gastrointestinal

(7) neurologic

 

Organ System

Finding

Score

cardiovascular

• mean arterial pressure > 70 mm Hg

• heart rate > 70 beats per minute

0

 

• mean arterial pressure 51-70 mm Hg

• heart rate 51 - 70 beats per minute

• ventricular tachycardia

1

 

• mean arterial pressure <= 50 mm Hg

• heart rate <= 50 beats per minute

• need for inotropic agents

• ventricular fibrillation

• cardiac arrest

• acute myocardial infarction

2

pulmonary

• PEEP <= 4 cm H2O

• FIO2 <= 0.3

• respiratory rate 12-24 per minute

0

 

• PEEP 5 - 9 cm H2O

• FIO2 > 0.3 and <= 0.4

• respiratory rate 6-11 per minute, or 25-49 per minute

1

 

• PEEP >= 10 cm H2O

• FIO2 > 0.4

• respiratory rate <= 5 per minute or >= 50 per minute

2

renal

serum creatinine <= 2.0 mg/dL

0

 

serum creatinine > 2.0 and <= 3.5 mg/dL

1

 

• serum creatinine > 3.5 mg/dL

• chronic renal insufficiency

• acute renal replacement therapy

2

hepatic

• bilirubin <= 2.0 mg/dL

• AST <= 25 U/L

0

 

• bilirubin > 2.0 and <= 3.0 mg/dL

• AST > 25 and <= 50 U/L

1

 

• bilirubin > 3.0 mg/dL

• AST > 50 U/L

• hepatic encephalopathy

2

hematologic

• hematocrit >= 30%

• WBC count >= 3,000 per µL

• platelet count > 100,000 per µL

0

 

• hematocrit 21-29%

• WBC count 290 - 3,000 per µL

• platelet count 51,000 - 100,000 per µL

1

 

• hematocrit <= 20%

• WBC count < 300 per µL

• platelet count <= 50,000 per µL

• DIC

2

gastrointestinal

normal functioning

0

 

• acalculous cholecystitis;

• stress ulcer not requiring blood transfusion

1

 

• bleeding from stress ulcer requiring > 2 units of blood in 24 hours;

• necrotizing colitis;

• necrotizing pancreatitis;

• perforation of viscus or gallbladder

2

neurologic

Glasgow coma score 13-15

0

 

Glasgow coma score 7-12

1

 

Glasgow coma score <= 6

2

(Table I, page 22)

 

where:

• mean arterial pressure = ((2 * (diastolic pressure)) + (systolic pressure)) / 3

• "acute renal replacement therapy" I infer to mean dialysis

• The WBC count entry in original tables says that a score of 2 is assigned if the WBC <= 3,000 per µL, which overlaps with the assignment  for a score of 1.

 

MOSF score =

= SUM(score for all 7 organ systems)

 

Interpretation:

• minimum score: 0

• maximum score: 14

• The higher the MOSF score, the higher the mortality rate.

 

According to Figure 4, page 28:

 

estimated mortality in percent =

= (8.18 * (MOSF score)) - 18.86


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