Patients with myeloma who have a high LDH concentration at presentation have a worse prognosis.
An elevated serum LDH in a patient with myeloma may be associated with:
(1) a rapidly progressive course
(2) a shortened time to relapse following remission
(3) decreased survival time
(4) poor response to chemotherapy (nonresponders)
(5) more extensive bone marrow infiltration
Limitations:
• The cutoff for the serum concentration depends on the assay being used.
• The assay should be standardized.
• An elevated LDH may be due to other cause (hepatitis, hemolytic anemia, etc).
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Specialty: Hematology Oncology
ICD-10: ,
