Description

Helbok et al used a multi-organ dysfunction score (MODS) to evaluate patients with uncomplicated Plasmodium falciparum malaria. This is based on the MODS reported by Weiler et al.


 

Number of organs evaluated: 10

 

The evaluation is performed within the first 24 hours of the hospital admission.

 

Organs:

(1) heart

(2) blood vessel (includes blood pressure)

(3) blood

(4) respiratory system

(5) metabolism

(6) gastrointestinal tract

(7) liver

(8) kidney and urinary tract

(9) immune system

(10) central nervous system (CNS)

 

where:

• 4 additional systems were not included in the evaluation - skin, bone, peripheral nervous system (PNS) and potluck (connective tissue/endocrine/pancreas).

 

Each system is graded according to the following scheme.

Organ Function

Points

normal

1

impaired function but compensated after conventional therapy

2

major organ dysfunction but compensated after maximal therapy

3

major organ dysfunction not partially compensated after maximal therapy

4

organ failure with poor prognosis

5

 

total MODS =

= SUM(points for all 10 systems)

 

Interpretation:

• minimum score: 10

• maximum score: 50

• The higher the score the more severe the malaria.

• Another measure would be the number of items with score 3, with score 4 and with score 5. In the study reported no patient had a score of 4 or 5.

 


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