Cozijnsen et al reported the mucosal inflammation noninvasive index (MINI) for pediatric patients with Crohn's disease. This provides a noninvasive method to determine the level of mucosal inflammation between endoscopic biopsies. The authors are from multiple institutions from around the world.
Patient selection: pediatric patient with Crohn's disease
Parameters:
(1) stool features
(2) fecal calprotectin in micrograms per gram stool
(3) ESR in mm/h and CRP in mg/L
Parameter
Finding
Points
stool
0 or 1 normal or liquid stools per day, no blood
0
2 to 5 liquid stools
4
0 to 2 semiformed with small amount of blood
4
>= 6 liquid
8
nocturnal diarrhea
8
gross bleeding
8
fecal calprotectin
< 50 µg/g
-3
50 to 99.9
0
100 to 299.9
5
300 to 599.9
7
600 to 899.9
9
>= 900
12
ESR and CRP
ESR < 10 and CRP < 5
0
ESR from 10 to 29
1
ESR from 30 to 49
2
ESR >= 50
5
CRP from 5 to 9.9
1
CRP from 10 to 29.9
2
CRP >= 30
5
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: -3
• maximum score: 25
• The higher the score the greater the inflammation.
Score
Status
< 8
mucosal healing
8 to 11
mild inflammation
> 11
moderate to severe inflammation
Performance:
• The area under the ROC curve to detect mucosal healing was 0.92.
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