Alarcon et al graded MRI changes in the brain associated with congenital cytomegalovirus (CMV) infection. The authors are from Oxford University Hospitals, Hammersmith Hospital, Sant Joan de Deu University Hospital (Barcelona) and La Paz University Hospital (Madrid).
Exam: brain MRI
Ventriculomegaly: ventricular index > 97th percentile for gestational age in mm
Severe ventriculomegaly: ventricular index > 97th percentile in mm + 4 mm
Parameters:
(1) calcifications
(2) vasculopathy
(3) germinolysis
(4) ventricular index
(5) white matter signal abnormalities
(6) cortical changes
(7) corpus callosum
(8) cerebellar
Parameter
Finding
Points
calcifications
none
0
single punctate periventricular
1
multiple discrete periventricular
2
extensive
3
vasculopathy
none
0
lenticulostriate
1
germinolysis
none
0
caudothalamic germinolysis
1
paraventricular germinolytic cysts
2
ventricular index
normal
0
ventriculomegaly, less than severe
1
ventriculomegaly, severe
2
white matter abnormalities
none
0
focal or multifocal white matter signal abnormalities
