Morvan syndrome is a rare autoimmune neurologic syndrome..

Target: Kv1 voltage-gated potassium channel (VGKC) complex


Autoantibodies include:

(1) CASPR2 = contactin associated protein 2

(2) LGl1 = leukcine-rich glioma inactivated 1


It may occur as a paraneoplastic syndrome in a patient with thymoma.


Clinical features:

(1) acquired neuomyotonia (peripheral nerve hyperexcitability that causes spontaneous muscular activity)

(2) mood changes

(3) hallucinations

(4) insomnia

(5) confusion or disorientation

(6) autonomic dysfunction

(7) in patients with anti-LGl1 there can be cardiac abnormalities (bradycardia, arrhythmia, AMI-like ECG changes)

(8) variable ataxia

(9) variable hyponatremia

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