Sprung et al identified a number of factors associated with mortality in a patient with the sepsis syndrome. These can help to identify a patient who may benefit from more aggressive management or a novel therapy. The authors are from the Veterans Administration Systemic Sepsis Cooperative Study Group.


Patient selection: sepsis syndrome


Independent predictors of mortality:

(1) altered mental status (encephalopathy), either acute or pre-existing

(2) hypothermia (temperature < 96°F) or normothermia (not febrile with temperature > 102°F)

(3) hypotension (systolic blood pressure < 90 mm Hg)

(4) thrombocytopenia (< 100,000 per µL)

(5) absence of shaking chills


To read more or access our algorithms and calculators, please log in or register.