Hill et al developed an index for evaluating renal biopsies from a patient with lupus nephritis. One component is the glomerular activity index (GAI). The authors are from Hopitaux Broussais, St. Louis, Henri Mondor and Bichat in Paris.
Patient selection: lupus nephritis
Specimen: renal biopsy
Parameters:
(1) glomerular proliferation (glprolif)
(2) polymorphonuclear leukocytes (glpmn)
(3) karyorrhexis/fibrinoid necrosis (karyfib)
(4) cellular cresecents (cresc)
(5) hyaline deposits (hyaldep)
(6) glomerular monocytes (glmono)
Each parameter is scored according to the severity of the finding.
Severity of Change
Points
none
0
mild
1
moderate
2
severe
3
glomerular activity index =
= (points for glomerular proliferation) + (points for polymorphonuclear leukocytes) + (2 * (points for necrosis)) + (2 * (points for cellular crescents)) + (points for hyaline deposits + (points for glomerular monocytes)
Interpretation:
• minimum score: 0
• maximum score: 24
• The higher the score the greater the glomerular involvement.
To read more or access our algorithms and calculators, please log in or register.
