Schrappe et al listed criteria for failure of induction therapy for a patient with acute lymphoblastic leukemia (ALL). Induction failure may be associated with a worse prognosis for the patient. The authors are from multiple institutions in North America and Europe.
Patient selection: acute lymphoblastic leukemia (ALL) following induction therapy (therapy intended to induce a remission)
Morphologic criteria for induction failure - one or both of the followng:
(1) >= 5% blasts in the bone marrow at the end of induction therapy
(1a) M3 (>= 25% blasts)
(1b) M2 (5 to 24.9% blasts)
(2) blasts present at an extramedullary site at the end of the induction therapy
A remission after induction therapy involves both of the following:
(1) < 5% blasts in the bone marrow (M1)
(2) no blasts at any extramedullary sites
With remission there should be no blasts in the peripheral blood.
To read more or access our algorithms and calculators, please log in or register.
