Monocytosis is a poor prognostic factor for a patient with primary myelofibrosis. It may appear before the onset of an accelerated disease phase.

Patient selection: primary myelofibrosis


Risk factors for a poor prognosis:

(1) monocytosis, with absolute monocyte count > 1,000 per microliter

(2) myelomonocytic proliferation in the bone marrow


Accelerated disease may show:

(1) circulating blasts

(2) worsening anemia

(3) worsening thrombocytopenia

(4) leukocytosis

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