Monocytosis is a poor prognostic factor for a patient with primary myelofibrosis. It may appear before the onset of an accelerated disease phase.
Patient selection: primary myelofibrosis
Risk factors for a poor prognosis:
(1) monocytosis, with absolute monocyte count > 1,000 per microliter
(2) myelomonocytic proliferation in the bone marrow
Accelerated disease may show:
(1) circulating blasts
(2) worsening anemia
(3) worsening thrombocytopenia
(4) leukocytosis
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Specialty: Hematology Oncology
