Chun et al used changes in the computed tomography (CT) appearance of liver metastases from a colonic carcinoma to determine the response of a patient to bevacizumab. The authors are from M.D. Anderson Cancer Center
Parameter seen in CT scans:
(1) overall attenuation
(2) interface between the metastasis and the adjacent liver
(3) peripheral rim of enhancement (may or may not be present initially)
|
Attenuation |
Interface |
Peripheral Rim |
CT Morphologic Group |
|
homogeneous and hypoattenuating |
sharp |
completely resolved (if present initially) |
1 |
|
mixed |
mixed |
partially resolved (if present initially) |
2 |
|
heterogeneous |
ill-defined |
still present (if present initially) |
3 |
|
Initial Appearance |
Appearance After Therapy |
Therapeutic Response |
|
group 3 |
group 1 |
optimal |
|
group 2 |
group 1 |
optimal |
|
group 3 |
group 2 |
incomplete |
|
group 3 |
group 3 |
none (unchanged) |
|
group 2 |
group 2 |
none (unchanged) |
|
group 2 |
group 3 |
none (progression) |
|
group 1 |
group 2 |
none (progression) |
|
group 1 |
group 3 |
none (progression) |
|
group 1 |
group 1 |
uncertain |
If multiple tumors are present then response is based on the response seen in the majority of the tumors.
The presence of new lesions was defined as progression.
Specialty: Hematology Oncology, Surgery, general
