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Monitoring Drugs Using the Concentration in Saliva

Specialty:

Clinical Pharmacology & Toxicology
Emergency Medicine & Critical Care
Emergency Medicine & Critical Care

Objective:

ICD-10:

Description:

Drug levels in saliva can be used to estimate the plasma drug level, which can be useful when it is difficult or undesirable to obtain plasma for monitoring. Transfer of a drug across membranes from the plasma into the saliva is only available for the nonionized and unbound drug fraction. For some drugs the drug level in the saliva may be the same as the unbound drug level in the plasma.

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