A colorectal carcinoma can be classified based on its pattern of microsatellite instability (MSI) and CpG Island Methylator phenotype (CIMP).
Parameters:
(1) microsatellite instability (MSI): MSI-H, MSI-L, MSS
(2) CpG island methylator phenotype (CIMP): CIMP-H, CIMP-L, CIMP-0
|
MSI Category |
CIMP Category |
Group |
|
MSI-H |
CIMP-H |
1 |
|
MSI-H |
CIMP-L |
2 |
|
MSI-H |
CIMP-0 |
2 |
|
MSI-L |
CIMP-H |
3 |
|
MSI-L |
CIMP-L |
4 (supergroup) |
|
MSI-L |
CIMP-0 |
6 (supergroup) |
|
MSS |
CIMP-H |
3 |
|
MSS |
CIMP-L |
5 (supergroup) |
|
MSS |
CIMP-0 |
6 (supergroup) |
|
Group |
Percent of Colon Cancers |
|
1 |
10% |
|
2 |
5% |
|
3 |
5 to 10% |
|
4 |
5% |
|
5 |
30 to 35% |
|
6 |
40% |
Groups 4, 5 and 6 can be combined into a single group lacking MSI-H and/or CIMP-H. This would represent 75 to 80% of colorectal carcinomas.
Specialty: Hematology Oncology, Surgery, general, Gastroenterology
ICD-10: ,
