Description

Akin et al used a modified SOFA-RV score for evaluating a patient with cardiogenic shock on veno-arterial ECMO or other mechanical circulatory support.  The authors are from Erasmus MC, Haga Teaching Hospital, Columbia University, Langone Medical Center and Pontificia Universidad Catolica de Chile.


Patient selection: cardiogenic shock on veno-arterial ECMO or other mechanical circulatory support

 

Parameters (SOFA score plus right ventricular score):

(1) PaO2 to FIO2 ratio and/or mechanical ventilation

(2) platelet count per microliter

(3) Glasgow coma scale (GCS)

(4) serum total bilirubin in mg/dL

(5) mean arterial pressure (MAP) in mm Hg or vasopressor therapy (in µg per kg per min)

(6) serum creatinine in mg/dL

(7) right ventricular score

 

Parameter

Finding

Points

PaO2 to FIO2 ratio

>= 400

0

 

300 to 399

1

 

200 to 299

2

 

100 to 199 and mechanically ventilated

3

 

< 100 and mechanically ventilated

4

platelet count

>= 150,000 per µL

0

 

100,000 to 149,999 per µL

1

 

50,000 to 99,999 per µL

2

 

20,000 to 49,999 per µL

3

 

< 20,000 per µL

4

Glasgow coma scale

15

0

 

13 or 14

1

 

10 to 12

2

 

6 to 9

3

 

3 to 5

4

serum total bilirubin

< 1.2 mg/dL

0

 

1.2 to 1.9 mg/dL

1

 

2.0 to 5.9 mg/dL

2

 

6.0 to 11.9 mg/dL

3

 

>= 12 mg/dL

4

mean arterial pressure (with vasopressor)

>= 70 mm Hg

0

 

< 70 mm Hg

1

pressors (with MAP)

none

0

 

dopamine <= 5 or any dose dobutamine

2

 

dopamine > 5; epinephrine or norepinephrine <= 0.1

3

 

epinephrine or norepinephrine > 0.1

4

serum creatinine

< 1.2 mg/dL

0

 

1.2 to 1.9 mg/dL

1

 

2.0 to 3.4 mg/dL

2

 

3.5 to 4.9 mg/dL

3

 

>= 5 mg/dL

4

right ventricular score

LV failure and normal RV function

0

 

LV failure and mild RV failure

1

 

isolated RV failure

2

 

LV failure and moderate RV failure

3

 

LV failure and severe RV failure

4

 

total score =

= SUM(points for all of the parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 28

• The higher the score the worse the prognosis.

• A score > 14 had a 30-day overall survival of 44% vs 74% for a score<= 14.

 

Performance:

• The area under the ROC curve is 0.70.


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