A modified version of the Rose index (see 04.13.02) was used by the Canadian Apheresis Group to evaluate patients with thrombotic thrombocytopenic purpura (TTP) and hemolytic uremic syndrome (HUS).
(1) neurological findings
(2) serum creatinine at presentation, indicative of renal impairment
(3) platelet count
< 132 µmol/L (no renal impairment)
132 - 221 µmol/L
> 221 µmol/L
> 100,000 per µL
20,000 - 100,000 per µL
< 20,000 per µL
> 12.0 g/dL
9.0 - 12.0 g/dL
< 9.0 g/dL
• The changes from the original index include simpler handling of the neurological findings and renal impairment.
total score =
= SUM(points for all 4 parameters
• minimum score: 0
• maximum score 7
• The higher the score the more severe the disease.
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Specialty: Hematology Oncology, Clinical Laboratory