Kim et al extended the MALT-IPI of Thieblemont et al by inclusion of serum betta-2-microglobulin. This can help to better classify patient risk. The authors are from multiple institutions in South Korea.
Patient selection: MALT lymphoma (extranodal marginal-zone lymphoma of mucosa-associated tissue)
Parameters:
(1) components of the MALT-IPI
(1a) age >= 70 years
(1b) Ann Arbor Stage III or IV
(1c) serum LDH > ULN
(2) serum beta-2-microglobulin in mg/L (upper limit of normal 2.5 mg/L)
Parameter
Finding
Points
age
< 70 years
0
>= 70 years
1
Ann Arbor stage
I or II
0
III or IV
1
serum LDH
<= ULN
0
> ULN
1
beta-2-microglobulin
<= 2.5 mg/L
0
> 2.5 mg/L
1
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
Total Score
Risk Group
5-Year OS
0
low
99.5%
1
intermediate
97.7%
>= 2
high
83.8%
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