Dean et al identified risk factors for a poor quality of life in a patient with ankylosing spondylitis that are potentially modifiable. These can identify possible targets for interventions. The authors are from the University of Aberdeen.

Patient selection: ankylosing spondylitis


Independent predictors:

(1) moderate or severe fatigue (odds ratio 1.6)

(2) poor physical function (BASFI >= 4; odds ratio 3.5)

(3) chronic widespread pain (odds ratio 1.9)

(4) high disease activity (BASDAI >= 4; odds ratio 1.5)

(5) poor spinal mobility (BASMI >= 4; odds ratio 1.5)


The quality of life declines as the number of predictors increase.

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