Warady et al reported models for the progression of kidney disease in children. One model was for children with glomerular kidney disease. The authors are from multiple institutions in the United States.
Patient selection: pediatric patient with glomerular kidney disease from 1 to 16 years of age
Outcome: progression of kidney dysfunction with either initiation of renal replacement therapy (dialysis or transplant) or a 50% reduction in GFR
Parameters:
(1) GFR in mL per min per 1.73 square m
(2) serum albumin in g/dL
(3) blood pressure percentile
(4) nephrotic proteinuria (urine protein to creatinine ratio > 2 mg per mg)
(5) anemia (< 5th percentile for age and sex)
Parameter
Finding
Points
GFR
>= 45
0
< 45
-2.01
serum albumin
>= 3.8 g/dL
0
< 3.8 g/dL
-0.38
blood pressure
<= 90th percentile
0
> 90th percentile
-0.60
nephrotic proteinuria
onset
-1.17
persistent
-1.35
resolution
-2.37
none
0
anemia
onset
-0.37
persistent
-1.35
resolution
-0.18
none
0
total score =
= SUM(points for all 5 parameters) + 3.97
median time to composite event in years =
= EXP(total score)
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