Models of Josephson et al for Predicting Psychiatric Adverse Effects Associated with Levetiracetam Therapy: Model Including Pre-Existing Mental Health Disorder
Levetiracetam is an antiepileptic medication that can cause psychiatric adverse effects. Johnson et al reported a model for identifying a patient at risk. The authors are from the University of Calgary and Icahn School of Medicine.
Patient selection: Levetiracetam
Outcome: adverse psychiatric effect within 2 years of starting therapy
Parameters:
(1) sex
(2) history of depression
(3) history of anxiety
(4) history of recreational drug use
Parameter
Finding
Points
sex
male
0
female
0.27
history of depression
no
0
yes
0.82
history of anxiety
no
0
yes
0.47
history of recreational drug use
no
0
yes
0.74
value of X =
= SUM(points for all 4 parameters) - 2.34
probability of a psychiatric adverse effect =
= 1 / (1 + EXP((-1) * X))
An additional risk factor was low socioeconomic status.
Number of Risk Factors
Percent Adverse Effect
0
8%
1
11-17%
2
17-31%
3
30-42%
4
49%
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