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Models of Hu et al for Mortality Associated with an Acute Exacerbation of COPD

Description

Hu et al evaluated the role of D-dimer and other risk factors in the prediction of mortality for a patient hospitalized for an acute exacerbation of COPD. These can help to identify a patient who may benefit from more aggressive management. The authors are from the Third Affiliated Hospital of Guangzhou Medical University, People's Hospital of Guangxi Zhuang Autonomous Region and the first Affiliated Hospital of Guangzhou Medical University.


Patient selection: adult with an acute exacerbation of COPD

 

Outcomes: in-hospital and 1-year mortality

 

Risk factors for in-hospital mortality:

(1) congestive heart failure (CHF)

(2) D-dimer >= 985 ng/L

 

Risk factors for 1-year mortality:

(1) serum CRP in mg/L (odds ratio 1.004 per mg/L)

(2) congestive heart failure (CHF, odds ratio 3.0))

(3) renal dysfunction (eGFR < 90 mL per min per 1.73 square meter, odds ratio 2.2)

(4) D-dimer >= 985 ng/L (odds ratio 2.0)

 

where:

• The method and reference range for D-dimer and for CRP were not reported.

• A serum CRP of 173 mg/L approaches an odds ratio of 2.0, so will use >= 175 in the implementation).


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