Halabi et al reported models for patients with Clostridium difficile. One model if a patient with Clostridium difficile disease is likely to progress to colectomy. The authors are from the University of California at Irvine.
Patient selection: Clostridium difficile
Parameters:
(1) coagulopathy
(2) weight loss
(3) teaching hospitals
(4) fluid and electrolyte abnormalities
(5) size of the hospital
(6) chronic lung disease
(7) hypothyroidism
(8) depression
(9) diabetes
(10) chronic liver disease
(11) hypertension
(12) race
(13) deficiency anemia
(14) neurologic disorder
Parameter
Finding
Beta-Coefficient
coagulopathy
no
0
yes
1.0
weight loss
no
0
yes
0.81
teaching hospital
no
0
yes
0.32
fluid/electrolyte abnormality
no
0
yes
0.27
size of hospital
large
0.16
small
-0.15
medium
0
chronic lung disease
no
0
yes
0.09
hypothyroidism
no
0
yes
-0.03
depression
no
0
yes
-0.04
diabetes
no
0
yes, uncomplicated
-0.08
yes, complicated
-0.19
chronic liver disease
no
0
yes
-0.09
hypertension
no
0
yes
-0.11
race
African-American
-0.13
other
0
deficiency anemia
no
0
yes
-0.21
neurologic disorder
no
0
yes
-0.33
value of X =
= SUM(all of the beta-coefficients) - 5.47
probability of progression to colectomy =
= 1 / (1 + EXP((-1) * X))
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