Halabi et al reported models for patients with Clostridium difficile. One model if a patient with Clostridium difficile disease is likely to die after a colectomy. The authors are from the University of California at Irvine.
Patient selection: Clostridium difficile, status post colectomy
Parameters:
(1) coagulopathy
(2) weight loss
(3) fluid and electrolyte abnormalities
(4) chronic lung disease
(5) hypothyroidism
(6) depression
(7) chronic liver disease
(8) deficiency anemia
(9) age in years
(10) acute renal failure
(11) respiratory failure
(12) sepsis or septic shock
(13) peripheral vascular disease
(14) congestive heart failure
(15) chronic kidney disease
(16) obesity
(17) drug abuse
(18) blood loss anemia
|
Parameter |
Finding |
Beta-Coefficient |
|
coagulopathy |
no |
0 |
|
|
yes |
0.87 |
|
weight loss |
no |
0 |
|
|
yes |
-0.32 |
|
fluid/electrolyte abnormality |
no |
0 |
|
|
yes |
0.21 |
|
chronic lung disease |
no |
0 |
|
|
yes |
0.06 |
|
hypothyroidism |
no |
0 |
|
|
yes |
-0.13 |
|
depression |
no |
0 |
|
|
yes |
-0.14 |
|
chronic liver disease |
no |
0 |
|
|
yes |
0.02 |
|
deficiency anemia |
no |
0 |
|
|
yes |
-0.18 |
|
age in years |
<= 60 years |
0 |
|
|
> 60 years |
0.68 |
|
acute renal failure |
no |
0 |
|
|
yes |
0.51 |
|
respiratory failure |
no |
0 |
|
|
yes |
0.47 |
|
sepsis or septic shock |
no |
0 |
|
|
yes |
0.34 |
|
peripheral vascular disease |
no |
0 |
|
|
yes |
0.33 |
|
congestive heart failure |
no |
0 |
|
|
yes |
0.22 |
|
chronic kidney disease |
no |
0 |
|
|
yes |
0.12 |
|
obesity |
no |
0 |
|
|
yes |
-0.01 |
|
drug abuse |
no |
0 |
|
|
yes |
-0.28 |
|
blood loss anemia |
no |
0 |
|
|
yes |
-0.50 |
value of X =
= SUM(all of the beta-coefficients) - 1.62
probability of progression to colectomy =
= 1 / (1 + EXP((-1) * X))
Specialty: Infectious Diseases
