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Models of Christianen et al for Swallowing Dysfunction After Chemoradiation for Head and Neck Cancer: Problems Swallowing Soft Foods

Description

Christianen et al developed several predictive models for swallowing dysfunction following chemoradiation for head and neck cancer. One model predicts problems while swallowing soft foods. The authors are from University Medical Center Groningen and VU University Medical Center Amsterdam in The Netherlands.


Patient selection: head and neck cancer after chemoradiation

 

Outcome: problems swallowing soft foods

 

Parameters:

(1) mean radiation dose to middle pharyngeal constrictor muscle (PCM) in Gray (Gy)

(2) radiation technique (3D-CRT vs IMRT)

(3) age (18 to 65 vs > 65 years)

(4) tumor site (other site vs oropharynx/nasopharynx)

 

Radiation Technique

Points

3D-CRT

0

IMRT

1

 

 

Age

Points

18 to 65

0

> 65

1

 

 

Tumor Site

Points

oro or naso pharynx

1

Other

0

 

X =

= (0.061 * (mean dose to middle PCM)) – (0.912 * (points for radiation technique)) + (1.203 * (points for age)) + (1.122 * (points for tumor site)) – 5.83

 

probability of problems swallowing soft foods =

= 1 / (1 + EXP((-1) * X))

 

Performance:

• The area under the ROC curve was 0.79.


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