Chen et al reported models for predicting the severity of various stages of hemorrhagic fever with renal syndrome (HFRS) due to a Hantavirus infection. Changes shown by a patient may predict clinical deterioration. The authors are from Xi'an Jiaotong University, Fudan University and Shanghai University of Traditional Chinese Medicine in China.
Patient selection: nonfebrile stage of hantavirus-associated hemorrhagic fever with renal syndrome
Predictors of severe disease during the febrile stage:
(1) eGFR (positive value, OR 6.9), with significant decrease in early stages indicative of severe renal damage.
(2) lower serum sodium (OR 0.85)
(3) higher urine conductivity (OR 1.3)
(4) higher urine epithelial cell count (OR 1.1)
(5) higher number of urinary casts (OR 1.02)
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